Rheumatoide Arthritis (RA)

Catecholestrogens in Rheumatoid Arthritis (RA): Hidden Role

Mortality in Rheumatoid Arthritis (RA): factors associated with recording RA on death certificates

BACKGROUND Death certificates can be used to assess disease prevalence and incidence; however, rheumatoid arthritis (RA) often remains unreported in death certificates. We sought to determine to what extent RA is underreported and what demographic and clinical characteristics could predict mention of RA in the death certificate. METHODS We recruited 1328 patients with RA from private, public ...

Infection rates in patients from five rheumatoid arthritis (RA) registries: contextualising an RA clinical trial programme

OBJECTIVE Patients with rheumatoid arthritis (RA) have an increased risk of serious infections. Comparing infection rates across RA populations is complicated by differences in background infection risk, population composition and study methodology. We measured infection rates from five RA registries globally, with the aim to contextualise infection rates from an RA clinical trials population. ...

[Genetics and genomics in rheumatoid arthritis (RA): An update].

Rheumatoid arthritis is a chronic inflammatory autoimmune disease that affects approximately 0.5-1% of the general population and leads to chronic synovial inflammation, destruction of cartilage and bone, and disability. The heritability of rheumatoid arthritis has been estimated to be about 60%, while the contribution of HLA to heritability has been estimated to be 11-37%. Other genes, such as...

Genes and environment in arthritis: can RA be prevented?

Understanding of how interactions between genes and environment contribute to the development of arthritis is a central issue in understanding the etiology of rheumatoid arthritis (RA), as well as for eventual subsequent efforts to prevent the disease. In this paper, we review current published data on genes and environment in RA as well as in certain induced animal models of disease, mainly th...